Thermal Cyclers

High‑Performance Thermal Cyclers for Reliable PCR and qPCR Workflows

Thermal cyclers are essential instruments for accurate and efficient temperature cycling in PCR workflows, supporting everything from routine DNA amplification to advanced real‑time qPCR analysis.

MIDSCI™ offers a complete selection of PCR and qPCR instruments designed to deliver precise temperature control, fast ramp rates, secure heated‑lid technology, and consistent results across research, diagnostics, and applied genomics applications. Whether you're optimizing annealing temperatures, running high‑throughput PCR plates, or performing multiplex real‑time assays, our thermal cyclers ensure dependable performance and reproducibility.

With touchscreen interfaces, gradient block options, multiple plate formats, and compatibility with essential PCR consumables and reagents, our thermal cyclers simplify workflow setup and support accurate amplification for cloning, gene expression studies, sequencing prep, and more.

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PR1MA™ TC9639 Gradient Thermal Cycler

The PR1MA™ TC9639 Thermal Cycler provides consistent, reliable results for laboratories with medium to high throughput. From its large, touch-screen user interface to its unique, multi-format block, this cycler is loaded with features. The program wizard and 10 pre-installed programs make it easier than ever to get up and running.

The fully adjustable heated lid prevents condensation and evaporation of samples. Lid temperature can be programmed, and when the block temperature is below 35°C, the lid automatically shuts off. The heating and cooling of the block are precisely and accurately controlled within exceptionally tight tolerances by a proprietary algorithm that simulates sample temperature.

With the multi-format block, there is no need for the expense of multiple interchangeable blocks. The PR1MA™ TC9639 has the flexibility to accept 96 × 0.2 mL tubes, a 96-well plate, 0.2 mL strips or 39 x 0.5 mL tubes all in the same sample block. For protocol optimization, a gradient can be set up across the block. An optional in-situ adapter allows for the incubation of slides. Additionally, the unit may be purchased with a 384-well sample block.

Compatible with PR1MA™ and Accuris™ PCR reagents. For research use only.

A large, full-color touchscreen serves as the operations center where all functions are accessed. From the “Home” screen, simply touch an icon to view the last run program, enter the program library, or use the program wizard to quickly enter a protocol. In addition, icons for favorite programs can be added for faster access.

The program wizard guides users through quickly setting up a protocol on a single screen. Once entered, programs are shown graphically and can be edited by simply touching the step that requires modification. Time and temperature increments can be built into programs as well as slower ramp rates. Storage capabilities are unlimited; programs can be stored in public folders, private (password-protected) folders, or on a flash drive. The full virtual keyboard allows for alphanumeric naming of programs and folders.

 

Main Attributes

  • Gradient capabilities- ideal for protocol optimization
  • Intuitive touchscreen control- Works even when wearing gloves!
  • Upgraded software- Even easier to use than before!
  • No need for interchangeable blocks- multi-format accepts:
    • 0.2 mL tubes or strips (96)
    • 0.5 mL tubes (39)
    • 96-well PCR plate



Limited Time Promo!

 

For a limited time, enjoy special pricing on the

MultiGene™ OptiMax Gradient Thermal Cycler (TC9610)!

 

WAS $4,118 | NOW $2,382

 

Offer is valid 09/30/26 to 12/31/26 or while supplies last.

Cannot be combined with other offers or discounts. Not valid on previous purchases or institutional pricing.

Special price applies only to the item specified. Valid in the USA only.

All standard terms and conditions apply.


MultiGene™ OptiMax Thermal Cycler  


This simple-to-program PCR thermal cycler unit is compact in design and built to perform. Programming is intuitive with the large display and multiple pre-programmed templates supplied with the unit.

 

The OptiMax comes with standard built-in 2-step, temperature optimization, touchdown, and time increment protocols that are easy to adjust to meet your cycling needs. You can select lid temperature or turn it off depending on your needs. The faster ramp rates allow more work to be done in a workday.
 

 

Additional Thermal Cycler Product Features:

  • Unique Flexible Programming with FlexTemp™ technology
  • Fast ramp rates 5°C heating / 3.5°C cooling
  • Simple user interface
  • No condensation after overnight cooling at 4°C
  • 3-Year Warranty 

Distinct Heat Optimization

The MultiGene™ OptiMax employs a new protocol optimization process improving on older gradient features. This “Better than Gradient” capability allows users to select up to 6 distinct annealing temperatures to be run simultaneously. This is ideal for method optimization as well as applications like genotyping.

 

The OptiMax utilizes FlexTemp™ technology that effectively separates the 96-well plate into 6 – (4 x 4) temperature regions that allow you to pick the temperatures you want to test against. These regions are easily identified by the blue and black squares visible on the microplate platen. Instead of having the thermal cycler choose temperatures for you, you can choose any temperatures you want within a 24°C range.

 

The MultiGene™ OptiMax has a heating rate of 5°C /sec and a cooling rate of 3.5°C/sec. We have minimized overshooting and undershooting so that your reactions only see the temperatures they are supposed to see. This also leads to faster runs time.

 

Intuitive User Interface

The MultiGene™ OptiMax utilizes an intuitive user interface. This user interface is friendly to the laboratory environment and consistent with what our customers previously enjoyed in our earlier models. It can be used with lab gloves even if wet. We have improved the ramping speed and eliminated overshooting and undershooting which contributes to longer run times.

 

Fully Adjustable Heated Lid

The OptiMax’s heated lid is fully adjustable to provide optimum pressure for use with a broad range of tubes and microplates. For optimum performance, the lid can also be programmed to hold different temperatures between 60° to 65°C and 100° to 115°C. The OptiMax lid prevents condensation and slides away and back from the user to provide full access to samples and reduce the risk of coming in contact with a hot surface.
 

 

Item#:
ASPCRTC8


PR1MA™ LD032 Mini Thermal Cycler

  • "Mini" sized, 9 x 7 inch footprint
  • Capacity for 32 x 0.2 mL or 4 PCR Strips
  • Intuitive touchscreen control

"Mini-sized" doesn't have to mean a sacrifice on features and performance. PR1MA™'s LD032 Mini Thermal Cycler offers advanced programming features, easy-to-use software, and fast, reliable cycling but with a smaller block and lower price point.

 

Designed for lower throughput needs, the PR1MA™ LD032 Mini Thermal Cycler has a capacity for 32 x 0.2 mL tubes. The wells are arranged in a 4 x 8 format, allowing the block to accept strips of 8 as well as individual tubes. The block heats and cools very quickly - at rates as fast as 5°C/second. A proprietary algorithm controls block temperature, bringing samples quickly to the target temperature without any over- or under-shoot. Excellent block uniformity ensures consistency from sample to sample.

 

The operation of the thermal cycler is controlled from the large, full-color, touch screen. Icon-driven menus allow users to get running quickly. Programming is extremely simple and includes options for time and temperature increments/decrements, adjustable ramp rates, and auto pause and restart functions. More than 100 typical programs can be stored in memory and easily recalled. After a run, samples can be held at 4°C. An on-screen report is also available at the completion of a run.
 

The heated lid is self-adjusting - the spring-loaded platen in the lid comes firmly into contact with the tops of the tubes to prevent sample evaporation and condensation. There are no knobs to turn or levers to adjust. The temperature of the heated lid can be changed, or the heating function of the lid may be turned off.

 

With a footprint less than that of the average laboratory notebook, the PR1MA™ LD032 Mini Thermal Cycler will fit almost anywhere. Its reduced capacity block and economical price make the PR1MA™ LD032 Mini Thermal Cycler the perfect choice for lower throughput laboratories and educational facilities.


Limited Time Promo!


Limited Time Promo!

 

For a limited time, enjoy special pricing on the Azure Cielo 6 qPCR System (AIQ060)!

 

WAS $34,850 | NOW $16,895

 

Package Includes: Azure Cielo 6 qPCR System, Comprehensive analysis software, and 18-month warranty.

 

See flyer for more details.

 

Promo is valid until 12/31/26 or while supplies last.
Offer cannot be combined with other discounts or institutional pricing.
All
terms and conditions apply.

Azure Cielo™ qPCR Systems

The Azure Cielo™ Real-Time PCR system provide accuracy and sensitivity needed for research, with intuitive touch screen software.

  • Flexibility:  Engineered for a wide variety of qPCR applications, with high sensitivity and wide dynamic range.
  • Intelligent workflow: The user interface is a simple touch screen assay setup.  Protocols can be saved to make assay set up easy and reproducible.
  • Reliability: Cielo's optics and thermal block are designed to deliver the same uniformity and reproducibility over at least 1,000 qPCR experiments, giving you confidence in the reliability of the instrument.
  • Connectivity: An external PC is not required to run the instrument.
  • Data Transfer: This can be performed via Ethernet, Wi-Fi or USB.

Operation - A standalone qPCR system with 10.3” touchscreen interface
Optics - 3 or 6 dye channel filters with LED based excitation for multiplexing
Speed - Fiber optic detection system scans 16 wells simultaneously
Durability - Tested reliability for over 1000 continuous runs
Connectivity - Easily export data via Wi-Fi, ethernet, USB or LAN
Capacity - 96-well format for semi-skirted or un-skirted plates and tubes
Thermal Performance - Marlow Peltier based block with 12 temperature gradient zones, ramp rates up to 6.0°C/sec
Chemistry - Supports reaction volumes between 10 µl–150 µl, open source chemistry, including FAST ~20 minute run-times
Sensitivity - Detect 2-fold differences in target quantities in singleplex reactions and up to 1 copy of amplified DNA, 10 logs of dynamic range


Competitor Q uses a single light source to excite all samples.

Differences in light path length lead to differences in excitation, which requires normalization. Though Competitor Q has said that they do not require normalization dyes, this is not reflected in the data as the data CV values for replicates is significantly higher.

 

Why doesn’t the Cielo™ require ROX dye?

 The Cielo does not require ROX dye because it uses in-well detection technology. The light path for excitation and reading emission are collimated directly into the well. As such, the light path length is always the same for each well, so there is no need to normalize for varying light path length. The data from the Cielo is consistently uniform and reproducible.

Specifications

Dyes/ProbesAzure Cielo 3 AIQ030Azure Cielo 6 AIQ060
SYBR™ Green, EvaGreen™, FAM™xx
VIC®, HEX™, JOE™, CAL Fluor® 540, CAL Fluor® Orange 560xx
TAMRA™ x
ROX™, TEX®615, CAL Fluor® Red 610 x
Cy®5, Quasar®670, Liz®, Mustang Purple®xx
Cy®5.5 x

*Other dyes/probes are possible depending on the system configuration.

Proudly made in the USA! Click here for more made in America products!


TC-96 Turbo™ 2D Gradient Thermal Cycler

  • Exceptionally fast cycling – speeds up to 9°C/second
  • 2D Gradient for simultaneous optimization of annealing and denaturation temperatures
  • Large, folding 10” touch screen
  • Program wizard for quick and easy protocol entry
  • Optimize results with MIDSCI™ PCR reagents

The Benchmark™ TC-96 Turbo™ 2D Gradient Thermal Cycler is designed for fast cycling and quick protocol optimization. Exceptionally easy to program, the unit features tight temperature control and excellent block uniformity for consistent, reliable results.

 

Many thermal cyclers offer users the option to select a temperature gradient across the block to test a range of annealing temperatures simultaneously. The TC-96 Turbo™ offers a 2D gradient – across both the columns and rows – allowing for optimization of annealing and denaturation temperatures in the same run. The ability to optimize both steps provides for an increase in yield and specificity of complex or GC rich templates. Temperature ramp rates as fast as 9°C per second allow reactions to be performed quickly – up to 20% faster than other popular thermal cyclers. Temperature change is precisely controlled by a proprietary algorithm that simulates sample temperature and allows samples to arrive at the programmed temperature without any lag or overshoot.

 

All operating parameters are controlled and monitored from the large, full color, 10” touch screen. The screen can be angled toward the user for easy access and folded back against the instrument when not in use to save space. Entering and editing programs is intuitive with the program wizard. Programming features include adjustable ramp rates, temperature and time increments/decrements, password protected multi-user login and a memory for 30,000 programs.

 

TC-96 Turbo™ will accommodate 96 x 0.2 or 96 x 0.1 mL tubes as well as non-skirted 96 well plates. The height of the heated lid is auto-adjusting to prevent condensation for all of the accepted consumables. Temperature of the lid is adjustable.

 

Compatible with select MIDSCI™ PCR reagents, click here to see options.


*For research use only.

 

Specifications

 

Capacity96 x 0.2 mL tubes/strips, 96 x 0.1 mL tubes, 96 well plate (nonskirted)
Temp. Control Range0° to 105°C
Temp. ControlSimulated sample or block
Accuracy / Uniformity± 0.2°C / ± 0.2°C (at 90ºC)
Ramp Rate9°C / sec. (maximum)
Lid Temp30°C to 112°C (User Adjustable)
Program Memory30,000 programs onboard, unlimited with flash drive
Gradient range/differential - horizontal30°C to 105°C / 1°C to 42°C
Gradient range/differential - vertical30°C to 105°C / 0.1°C to 24°C
Increments/DecrementsYes, both time and temperature
Multiuser LoginYes, with password protection
Power Failure RestartYes
Power SupplyUniversal 75 to 275V 50 to 60 Hz; 1200W
Dimensions14.75 x 10.5 x 10.9 in. | 37.5 x 27 x 27.7 cm
Weight28.7 lbs. | 13 kg
Warranty2 years

 
MultiCycler™ Multi-block Thermal Cycler


Designed for laboratories wanting flexibility in their applications, Benchmark’s MultiCycler™ Thermal Cyclers offer multiple, independent cycling blocks in a single unit.

  • Dual or triple block models are available, both offering extremely fast cycling profiles
  • Large touchscreen interfaces
  • Self-adjusting heated lids
  • Gradient capabilities
  • Easy-to-use program wizard.

All programming features are accessed from the large, 10” full-color touch screen. The screen can be angled towards the user when in use and then tucked away to save space. A program wizard guides users through the simple protocol setup process. Advanced programming features include gradient, adjustable ramp rates, and time increments and decrements. For multi-user labs, password protection prevents interference with an existing run. A USB provides for unlimited program storage and easy transfer of protocols between MultiCycler™ machines.

The auto-adjusting heated lid prevents condensation and evaporation of samples. Lid temperature can be programmed, and when the block temperature is below 35°C, the lid automatically shuts off. Peltier units allow for exceptionally fast heating and cooling of the blocks. Temperature change is precisely and accurately controlled within tight tolerances by a proprietary algorithm that simulates sample temperature, resulting in fast runs and reproducible results.
 

The wells are arranged in a 4×8 and 6×8 format, allowing for the use of PCR strip tubes in both models. Each block is independently controlled.



Specifications

CapacityMultiCycler™ 332 - 3 x 32 well blocks
MultiCycler™ 248 - 2 x 48 well blocks
Heating and CoolingPeltier elements
Display10" full color touch screen with
adjustable angle
Block Temperature Range4°C to 99.9°C
Maximum Heating Rate7.5°C/sec
Maximum Cooling Rate6°C/sec
Ramp Rate Adjustment0.1°C to 5.0°C
Temperature Uniformity≤±0.2°C (at 90°C)
Temperature Accuracy≤±0.2°C (at 90°C)
Gradient FunctionalityYes, 8 different temps/block
Gradient Accuracy±0.1°C
Gradient Range30°C to 99.9°C
Heated LidYes, 30°C to 112°C
Power100-240V, 50-60Hz
Dimensions (L x W x H)37.5 x 27 x 27.7 cm
14.75 x10.5 x 10.9 in.
Weight13 kg/28.7 lbs
Warranty2 years


 

 

Item#:
ASMULICYCMULTB
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