Want to increase your cellular productivity? TPP Bioreactors boast up to 62% better oxygen transfer over Erlenmeyer flasks! Try our TPP bioreactor starter pack today!

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Want to increase your cellular productivity? TPP Bioreactors boast up to 62% better oxygen transfer over Erlenmeyer flasks! Try our TPP bioreactor starter pack today!
Want to increase your cellular productivity? TPP Bioreactors boast up to 62% better oxygen transfer over Erlenmeyer flasks! Try our TPP bioreactor starter pack today!
TP87600-3
TPP TubeSpin Bioreactor, 600mL
Conical Bottom, Filter Cap,
1/bag, 3/cs
$82.75
Want to increase your cellular productivity? TPP Bioreactors boast up to 62% better oxygen transfer over Erlenmeyer flasks! Try our TPP bioreactor starter pack today!
MIDSCI Web Pricing
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Want to increase your cellular productivity? TPP Bioreactors boast up to 62% better oxygen transfer over Erlenmeyer flasks! Try our TPP bioreactor starter pack today!



TubeSpin Bottle

 

TPP TubeSpin® Bioreactors have a proven track record in large scale screening and optimization processes of suspension cells. The optimization of the parameters, important for production up-scaling, can be evaluated with small amounts maximizing the number of parallel experiments at the same time.


Suspension cells ranging from immune cells to insect cells and microorganisms like E.coli to yeast can be cultured and centrifuged in TubeSpin® Bioreactors, eliminating the need for transferring before spinning down.

Features:

  • Optimal working volume 400mL
    • easy to start small suspension cell cultures from frozen
    • ergonomic use of bacterial and yeast cultures -- static and shaking
  • conical bottom
    • easy to see culture density
    • accentuates cyclonic aeration of nutrients & gas exchange
  • 0.2µM filter membrane
    • Sterile gas exchange
  • 10 openings of different size above the gas permeable, sterile PTFE filter of the screw cap
    • Optimal supply of oxygen through the openings
    • Openings can be sealed to adjust gas exchange according to need

Advantages:

    • Great gas exchange throughout the culture
      • Defined ventilation
    • Flexible working volume with one type of tube
      • No transfer stage - Spin down in the same tube
    • Large-scale parallel experiments
      • Rapid sampling following centrifugation, and the tube is disposable
      • No internal stirring mechanism to damage cells or produce foam
    • Less incubator or hood space needed; when compared to a T75
      • Less plastic usage and less plastic waste
      • Easier withdrawal from tube than a flask

Bacterial and Microbiological Cultures
TPP TubeSpin Tubes are ideally suited for the culture of bacteria, yeast, and other microbiological organisms in suspension.  The simple,disposable format offers convenience and time-savings over traditional glass vessels such as test tubes which must be washed and autoclaved before each use.  Both aerobic and anaerobic cultures can be grown by selectively covering the holes in the 0.22um filter cap.  Upto 400mL of culture can be grown in each TubeSpin bioreactor, offering the flexibility to perform mini plasmid preps, small-scale candidate screens, or other downstream applications.

The 600mL tube design contains no internal mixing or stirring mechanism which minimizes cell shearing and foam formation, and agitation is provided by shaking in a CO2 shaking incubator. In this manner, hundreds of cell cultivations can be performed quickly and efficiently in parallel.

    Information on TP87600

    Equipment 

    Rotational speed

    Surface comparison

    600ml bioreactors

     

    bioreator family

     

    Order # Description
    Working Volume (mL)
    Dimensions (mm)
    Max g Force
    Quantity
    TP87017 15mL Tubespin Bioreactors
    1-10 mL
    16.2x120
    9500
    800/cs
    TP87017-200 15mL Tubespin Bioreactors
    1-10 mL
    16.2x120
    9500
    200/cs
    TP87017-400 15mL Tubespin Bioreactors
    1-10 mL
    16.2x120
    9500
    400/cs
    TP87050 50 mL Tubespin Bioreactors
    1-35 mL
    30x115
    9500
    180/cs
    TP87050-60 50 mL Tubespin Bioreactors
    1-35 mL
    30x115
    9500
    60/cs
    TP87600 600 mL Tubespin Bioreactors
    400 mL
    98x181
    3500
    26/cs
    TP87600-3 600 mL Tubespin Bioreactors
    400 mL
    98x181
    3500
    3/cs
    TP87600-13 600 mL Tubespin Bioreactors
    400 mL
    98x181
    3500
    13/cs

    Please call us for sample!

    Literature and comprehensive information about shaking technology can be found in the "Forum Shaking Technology", a cooperation of TPP with competent partner companies.

    Incubator filled with Tubespin 50TPP adapter platePellets after being centrifuged 600ml

    Gas exchangehigh density O2

    Instruction for use

    Check out our information Flyer

    See the latest citations on the TubeSpin Bioreactors, click on their names to view the pdf file:

    Literature

    Posters

    TubeSpin® bioreactor 600: OrbiShake technology for suspension culture of CHO cells.
    Dominique T. Monteil, Saroj Ghimire, Giulia Tontodonati, Lucia Baldi, David L. Hacker, and Florian M. Wurm, Laboratory of Cellular Biotechnology, EPFL, CH-1015 Lausanne, Switzerland

    TubeSpin® bioreactors: Growth of and recombinant protein production in Sf-9 insect cells
    Xiao Shen, Patrik O. Michel, Lucia Baldi, David L. Hacker, and Florian M. Wurm
    Laboratory of Cellular Biotechnology, EPFL, CH-1015 Lausanne, Switzerland

    Publications

    pdfQiuling Xie et al: TubeSpin bioreactor 50 for the high density cultivation of Sf-9 insect cells in suspension. (2011)

    pdfStrnad et al: Optimization of Cultivation Conditions in Spin Tubes for Chinese Hamster Ovary Cells Producing Erythropoietin and the Comparison of Glycosylation Patterns in Different Cultivation Vessels (2010)

    pdfMaria J. De Jesus et al, TubeSpin satellites: a fast track approach for process development with animal cells using shaking technology, Biochemical Engineering Journal 17 (2004) 217–223

    pdfTibor Anderlei et al, Shaken Bioreactors Provide Culture Alternative Systems Have Evolved to the Point Where Scale-Up Is No Longer an Issue
    ,GEN_Nov 2009

    pdfMartin Jordan et al, A versatile disposable culture system for high throughput screening of process parameters and production cell lines.

    pdfMartin Jordan - Poster - A versatile disposable culture system for high throughput screening of process parameters and production cell lines.

    pdfMartin Jordan et al, Tools for High-Throughput Medium and Process Optimization

    pdfMatthieu Stettler et al, Novel Orbital Shake Bioreactors for Transient Production of CHO Derived IgGs

    pdfFlorian M. Wurm et al, Disposable orbital shake bioreactor system from ml to 1000 Liter for cell culture - from concept to reality

    pdfFlorian M. Wurm et al, Disposable TubeSpin® Bioreactor 600 offers superior cell culture performance and larger working volume for suspension cultures of mammalian cells.

    pdfEinwegbioreaktoren für die Prozessentwicklung mit Insektenzellen, 3:2009

    pdfKasper et al: Kultivierungsstrategien für Stammzellen, BIOforum 5_2009

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